—Steve Jobs at an Apple event introducing the iPad.
Apple introduced a successful UI design pattern with the iPhone. They stuck to it with the iPad.
Apple this to web design. If there is an accepted, or expected UI pattern, you should generally adhere to it.
Put the logo in the top left, or centre. Put the navigation in the top right. Use icons that people understand. Name things in a familiar way.
A good design get’s out of people’s way.